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Neda Barjesteh

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Professeure adjointe

Faculté de médecine vétérinaire - Département de pathologie et microbiologie

3200, rue Sicotte - aile A local 3901

neda.barjesteh@umontreal.ca

Travail 1 : 450 773-8521 #33191

Biographie

Neda Barjesteh a obtenu son D.M.V. à l’Université de Téhéran (Iran) en 2006. Entre 2007 et 2011, elle a travaillé à temps partiel dans le secteur privé dans le domaine de la médecine vétérinaire, qui incluait des activités de diagnostic et de consultation. Pendant cette même période, elle était aussi assistante de recherche affiliée à l’Université de Téhéran. En 2011, elle a joint l’Ontario Veterinary College de l’Université de Guelph comme visiteure de recherche et a entrepris des études de Ph.D. Elle a obtenu son diplôme en janvier 2017. Depuis 2017, elle poursuivait une formation postdoctorale à la Faculty of Health Sciences, McMaster University dans le domaine de la neuroinflammation. Elle est aujourd'hui professeure adjointe en immunologie au Département de pathologie et microbiologie de l'Université de Montréal.

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Recrutement recherche

Opportunity in Veterinary Viral Immunology for one Master of Science student Department of Pathology and Microbiology,
Faculty of Veterinary Medicine, University of Montreal

A Master of Science position is currently available at the laboratory of Dr. Neda Barjesteh, Department of Pathology and Microbiology, Faculty of Veterinary Medicine The University of Montreal to work on "Regulation of the antiviral innate responses: a new dimension in the host-pathogen interaction".The project will elucidate the complex interplay of the immune system, including the cross-talks of immune system cells, the role of exosomes and their contents, in enhancing antiviral immune responses against viral infections including avian influenza virus (AIV) in chickens. The emphasis will be on the cross-talk between different immune responses and control systems. Understanding the fundamental regulation of the innate responses through exosomes and microRNAs is presented to the implementation of innovative prophylactic strategies. This project offers an essential direction for future research to tailor antiviral immune responses in the context of viral infections.
The proposed project is novel and cross-disciplinary which will allow the trainee in my team to gain experience and knowledge in the fields of viral-immunology and biology.
The starting date is January 2019 or until a suitable applicant is identified.
Highly qualified and motivated students to their applications to Dr. Neda Barjesteh (neda.barjesteh@umontreal.ca). Applicants should also include a letter outlining their interests and qualifications for the position, academic grades and the curriculum vitae in their applications.
The successful candidate must have an interest in viral infections, immunology and veterinary medicine.

They should have a Doctorate in Veterinary Medicine or a Bachelor of Science degree in Microbiology, or any related fields.
Preference will be given to bilingual students (English and French).

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Expertises

Dr. Barjesteh’s research is focused on  understanding mechanisms involved in the regulation of innate responses in chickens in the context of viral infections, such as avian influenza A virus (AIV) infection with a goal to develop novel control and containment strategies. The novel strategies will be designed based on tailoring the innate responses in chickens and targeting the cells of the innate system, such as macrophages and dendritic cells in chickens.

We are currently pursuing the following investigations:

1-Elucidating the emerging roles of exosomes released from chicken airway epithelial cells in the regulation of the innate antiviral immune responses

2- Exploring the emerging roles of cellular stress responses in the regulation of the innate antiviral immune responses: a new dimension in the host-pathogen interaction

Publications Tout déplier Tout replier

  1. Stacy H., Barjesteh N., Mapletoft J.P., Miller M.S. (2018) “Gnothi Seauton": Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy. Vaccines (Basel). Apr 12; 6(2):pii: E23
  2. Alkie TN., Taha-Abdelaziz K., Barjesteh N., Bavananthasivam J., Hodgins DC, Sharif S. (2017) Characterization of innate responses induced by PLGA encapsulated- and soluble TLR ligands in vitro and in vivo in chickens. PLoS One. Jan 3;12(1): e0169154.
  3. Barjesteh N., Hodgins DC., Alkie TN., Nagy É., Sharif S. (2016) Local innate responses in the chicken trachea. Journal of Viruses. 22;8(7). pii: E207.
  4. Barjesteh N., Shojadoost B., Brisbin TJ., Emam M., Hodgins DC., Nagy É., Sharif S. (2015) Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens. Vaccine. Sep 11;33(38):4843-9.
  5. Barjesteh N., Brisbin TJ., Behboudi S., Nagy É., Sharif S. (2015) Induction of antiviral responses against avian influenza virus in embryonated chicken eggs with TLR ligands. Viral Immunol. May;28(4):192-200.
  6. Hodgins DC. §, Barjesteh N. §, St. Paul M., Ma Z., Monteiro M., Sharif S. (2015) Evaluation of a polysaccharide conjugate vaccine to reduce colonization by Campylobacter jejuni in broiler chickens. BMC Res Notes. Jun 2;8(1):204. § These authors contributed equally to the work
  7. Haq K., Wotton S., Barjesteh N., Bendall B., Sharif S. (2015) Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens. Can J Vet Res. 2015 Jan;79(1):1-7
  8. Alkie TN., St Paul M., Barjesteh N., Brisbin TJ., Sharif S. (2014) Expression profiles of antiviral response genes in chicken bursal cells stimulated with Toll-like receptor ligands. Vet Immunol Immunopathol. 2015 Feb 15;163(3-4):157-63.
  9. Barjesteh N., Behboudi S., Brisbin TJ., Villaneueva AI., Nagy É., Sharif S. (2014) TLR ligands induce antiviral responses in chicken macrophages. PLoS One. 28;9(8):e105713
  10. St. Paul M., Barjesteh N., Brisbin TJ., Villaneueva AI., Read LR., Hodgins DC., Nagy É., Sharif S. (2014) Effects of Toll-like receptor 3, 4 and 21 ligands as adjuvants on the immunogenicity of an avian influenza vaccine in chickens. Viral Immunol. 27(4):167-73.
  11. St. Paul M., Brisbin TJ., Barjesteh N., Villaneueva AI., Parvizi p., Read LR., Nagy É., Sharif S. (2014) Avian influenza virus vaccines containing Toll-like receptor 2 and 5 ligand adjuvants promote protective immune responses in chickens. Viral Immunol. 27(4):160-6.
  12. Barjesteh N., Hodgins DC., St. Paul M., Quinteiro-Filho WM., DePass C., Monteiro M., Sharif S. (2013) Induction of chicken cytokine responses in vivo and in vitro by lipooligosaccharide of Campylobacter jejuni HS:10. Vet Microbiol. 31;164(1-2):122-30.
  13. Yitbarek A., Rodriguez-Lecompte JC., Echeverry HM., Munyaka P., Barjesteh N., Sharif S., Camelo-Jaimes G. (2013). Performance, histomorphology, and toll-like receptor, chemokine, and cytokine profile locally and systemically in broiler chickens fed diets supplemented with yeast-derived macromolecules. Poult Sci. 2013 Sep;92(9):2299-310.
  14. Emam M., Mehrabani-Yeganeh H., Barjesteh N., Nikbakht G., Thompson-Crispi K., Charkhkar S., Mallard B. (2013) The influence of genetic background versus commercial breeding programs on chicken immunocompetence. Poult Sci. 93(1):77-84.
  15. Nikbakht G., Esmailnejad A., Barjesteh N. (2013) LEI0258 microsatellite variability in Khorasan, Marandi, and Arian chickens. Biochem Genet. 51(5-6):341-9. 
  16. Haq K., Wotton S., Barjesteh N., St. Paul M., Golovan S., Bendall B., Sharif S. (2013) Small interfering RNA-mediated knockdown of chicken interferon-gamma expression. J Interferon Cytokine Res. 33(6):319-27.
  17. St. Paul M., Paolucci S., Barjesteh N., Wood RD., Sharif S. (2013) Chicken erythrocytes respond to Toll-like receptor ligands by up-regulating cytokine transcripts. Res Vet Sci. 95(1):87-91.
  18. St. Paul M., Paolucci S., Barjesteh N., Wood RD., Schat KA., Sharif S. (2012) Characterization of chicken thrombocyte responses to Toll-like receptor ligands. PLoS One. 2012;7(8):e43381.
  19. St. Paul M., Barjesteh N., Paolucci S., Pei Y, Sharif S. (2012) Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res Notes. 2012 Nov 1;5:616. 
  20. Brujeni GN., Poorbazargani TT., Nadin-Davis S., Tolooie M., Barjesteh N. (2010) Bovine immunodeficiency virus and bovine leukemia virus and their mixed infection in Iranian Holstein cattle. J Infect Dev Ctries. 4(9):576-9
  21. Bazargani TT., Tooloei M.; Broujeni G., Garagozlo M. J., Bokaei S., Khormali M., Barjasteh N. (2010) The first study of BIV infection and clinical, pathological, heamatological and flowcytometric disorders in Iranian Holstein. J Vet Res. 65(1):1-11
  22. Brujeni GN., Barjesteh N. (2009) A study of the genotypic variability at the MHC (B-F) in Arian broiler chickens by PCR-SSCP. J Vet Res. 64(4):63-7
  23. Brujeni GN., Emam SM., Homayounzadeh M., Barjesteh N. (2008) Study on IFN-γ gene polymorphism in Shaul sheep. J Vet Res. 63(3):199-204
  24. Brujeni GN, Emam SM., Barjesteh N. (2008) Evaluation of immunoprecipitation method to isolate lymphosarcoma BLV induced Antigens.  J Vet Res. 63(3): 141-6.

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