Maîtrise - CRIPA et GREMIP
Direction: Mariela Segura
Evaluation and improvement of vaccines to protect piglets against Streptococcus suis infections
The candidate will be involved in an applied research project to test improvement strategies to increase the immunogenic capacity of autogenous vaccines in pigs.
April 15th, 2019. However, late applications will be considered on a rolling basis.
Streptococcus suis is the most important swine bacterial disease affecting pigs and it is also a zoonotic agent. Disease management in pigs is wearisome due to restrictions in antibiotic use and lack of proven effective vaccines. Currently, field immunization efforts focus on bacterins (autogenous vaccines) with contradictory results and, in many cases, vaccinations are initiated without detailed knowledge of immunological and protective responses induced by these vaccines.
In addition, there is lack of a standardized protocol for vaccine formulation and, more importantly, of scientific evaluation of the effect of formulation on vaccine efficacy. Adjuvants are key components in vaccine preparations and can dramatically influence the immune response to the vaccine antigen(s).
However, the effect of adjuvants on S.suis-bacterin protective capacity has never been scientifically evaluated. We propose to study and compare, for the first time, the immune response and protection generated by a bacterin formulated with different adjuvants under controlled conditions using experimental challenge of piglets.
The student will have the opportunity to learn a large animal infectious and immunization model (the pig), as well as vaccinology, immunology and bacteriology techniques.
18,000$ / year
From May 2019 to end 2020 (18-24 months)
Send your C.V. and copies of grade transcripts to the following address: firstname.lastname@example.org
This research project is funded by Ontario Pork