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Marilène Paquet

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Professeure agrégée

Faculté de médecine vétérinaire - Département de pathologie et microbiologie

1500, av. des Vétérinaires

Travail 1 : 450 773-8521 #49061

Télécopieur : 450 778-8116

Affiliations

Expertises

  • Oncologie comparée
  • Pathologie comparée et modèles animaux de maladie humaine
  • Physiopathologie du système reproducteur
  • Effets des toxines environnementales sur le système reproducteur

Encadrement Tout déplier Tout replier

Élucidation du rôle de la voie Hippo dans l’ovaire chez la souris Thèses et mémoires dirigés / 2018 - 2018
Diplômé(e) : Tsoi, Mayra
Cycle : Doctorat
Diplôme obtenu : Ph. D.
Ciblage thérapeutique de la voie Hippo pour le traitement des cancers mammaires chez la chienne Thèses et mémoires dirigés / 2017 - 2017
Diplômé(e) : Guillemette, Samantha
Cycle : Maîtrise
Diplôme obtenu : M. Sc.

Projets de recherche Tout déplier Tout replier

Regulation of gonadotropin action by Slit/Robo signaling in the mammalian orary Projet de recherche au Canada / 2018 - 2025

Chercheur principal : Derek Boerboom
Co-chercheurs : Marilène Paquet , Nicolas Gévry
Sources de financement : IRSC/Instituts de recherche en santé du Canada
Programmes de subvention : PVXXXXXX-(PJT) Subvention Projet

Negative Pressure Wound Therapy (NPWT) for open, contaminated wounds in horses Projet de recherche au Canada / 2016 - 2018

Chercheur principal : Christine Theoret
Co-chercheurs : Sheila Laverty , Marie Archambault , Marilène Paquet
Sources de financement : American College Veterinary Surgeons Foundation
Programmes de subvention :

Hippo pathway dysregulation in canine mammary gland tumorigenesis and it's potential as a novel therapeutic target Projet de recherche au Canada / 2016 - 2017

Chercheur principal : Marilène Paquet
Sources de financement : Morris Animal foundation
Programmes de subvention :

Publications Tout déplier Tout replier

Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, et al. Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. Cell reports. 2016;15(9):1893-900.

Boyer A, Girard M, Thimmahahalli DS, Levasseur A, Celeste C, Paquet M, et al. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biology of reproduction. 2016.

Labbe DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, et al. PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers. Cancer research. 2016;76(11):3130-5.

Lee T, Paquet M, Larsson O, Pelletier J. Tumor cell survival dependence on the DHX9 DExH-box helicase. Oncogene. 2016. doi: 10.1038/onc.2016.52. [Epub ahead of print].

Allaire JM, Roy SA, Ouellet C, Lemieux E, Jones C, Paquet M, et al. Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. International journal of cancer. 2016;138(11):2700-12.

Buensuceso AV, Son AI, Zhou R, Paquet M, Withers BM, Deroo BJ. Ephrin-A5 Is Required for Optimal Fertility and a Complete Ovulatory Response to Gonadotropins in the Female Mouse. Endocrinology. 2016;157(2):942-55.

Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(4):1534-47.

Nadeau ME, Rico C, Tsoi M, Vivancos M, Filimon S, Paquet M, et al. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC cancer. 2015;15:479.

Hai L, McGee SR, Rabideau AC, Paquet M, Narayan P. Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries. Biology of reproduction. 2015;93(1):16.

Boerboom D, Kumar V, Boyer A, Wang Y, Lambrot R, Zhou X, et al. beta-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015;156(1):323-33.

Stodden GR, Lindberg ME, King ML, Paquet M, MacLean JA, Mann JL, et al. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015;34(19):2471-82.

Dauphinee SM, Richer E, Eva MM, McIntosh F, Paquet M, Dangoor D, et al. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes and immunity. 2014;15(5):282-92.

Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, et al. Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARgamma. Hepatology (Baltimore, Md). 2014;59(5):1803-15.

Ramdzan ZM, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, et al. RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS biology. 2014;12(3):e1001807.

Shio MT, Paquet M, Martel C, Bosschaerts T, Stienstra S, Olivier M, et al. Drug delivery by tattooing to treat cutaneous leishmaniasis. Scientific reports. 2014;4:4156.

Eva MM, Yuki KE, Dauphinee SM, Schwartzentruber JA, Pyzik M, Paquet M, et al. Altered IFN-gamma-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. Journal of immunology (Baltimore, Md : 1950). 2014;192(1):259-70.

Lapointe E, Boyer A, Rico C, Paquet M, Franco HL, Gossen J, et al. FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biology of reproduction. 2012;87(5):104.

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