Alexandre Boyer
- Professeur agrégé
-
Faculté de médecine vétérinaire - Département de biomédecine vétérinaire
Pavillon 3200, rue Sicotte - Aile A office 1433
Travail 1 : 450 773-8521 #8345
Télécopieur : 450 778-8103
Web : Autre site web
B.Sc.
2000
, Biologie et autres sciences connexes , Université de Sherbrooke (Canada)
Ph.D.
2006
, Biologie moléculaire , Université de Montréal (Canada)
Stage postdoctoral: Molecular and Cellular Biology
2009
, Baylor College of Medicine (Canada)
Stage postdoctoral: Molecular Endocrinology
2011
, McGill University (Canada)
Affiliations
Expertises
Student supervision Expand all Collapse all
Cycle : Master's
Grade : M. Sc.
Cycle : Master's
Grade : M. Sc. A.
Research projects Expand all Collapse all
Roles, mechanisms of action and regulation of Hippo signaling in the testis Projet de recherche au Canada / 2020 - 2026
Roles, mechanisms of action and regulation of Hippo signaling in the testis Projet de recherche au Canada / 2020 - 2026
ELUCIDATION OF THE REGULATORY MECHANISMS OF SPERMATOGONIAL STEM CELL FATE Projet de recherche au Canada / 2014 - 2022
Développement et validation de nouvelles cibles épigénétiques de la douleur chronique chez l'animal arthrosique. Projet de recherche au Canada / 2019 - 2020
Réseau Québécois de Recherche sur la Douleur (RQRD) - Élucidation du rôle de la voie Hippo dans le contrôle de la douleur Projet de recherche au Canada / 2019 - 2020
Développement et validation de nouvelles cibles épigénétiques de la douleur chronique chez l'animal arthrosique. Projet de recherche au Canada / 2018 - 2019
Élucidation du rôle de la voie Hippo dans le contrôle de la douleur arthrosique / Réseau québécois de recherche sur la douleur / RQRD Projet de recherche au Canada / 2018 - 2019
Identification des mécanismes moléculaires et prévention de la toxicité reproductive mâle causée par des combinaisons de fusariotoxines (déoxynivalénol (DON), zéaralénone (ZEN) et fusomisine B1 (FB1) Projet de recherche au Canada / 2015 - 2015
(Bourse Christian Savard) Identification des mécanismes moléculaires et prévention de la toxicité reproductive mâle causée par des combinaisons de fusariotoxines (déoxynivalénol (DON), zéaralénone (ZEN) etfumonisine B1 (FB1) Projet de recherche au Canada / 2015 - 2015
Publications Expand all Collapse all
Boyer A, Girard M, Thimmanahalli D, Levasseur A, Céleste C, Paquet M, Duggavathi R, Boerboom D. mTOR regulates gap junction alpha-1 protein trafficking in Sertoli cells and is required for the maintenance of spermatogenesis in mice. Biology of reproduction, 2016, Jul;95(1):13.
Savard C, Nogues P, Boyer A, Chorfi Y. Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. Toxicology. 2016;341-343:17-27.
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(4):1534-47.
Tsoi M, Laguë MN, Boyer A, Paquet M, Nadeau ME, Boerboom D. Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor. Transl Oncol. 2013, 6(3):226-33.
Lapointe E, Boyer A, Rico C, Paquet M, Gossen J, DeMayo FJ, Richards JS, Boerboom D. Fzd1 regulates cumulus expansion genes and is required for normal female fertility. Biol Reprod. 2012, 87(5):104.
Boyer A, Yeh JR, Zhang X, Paquet M, Gaudin A, Nagano MC, Boerboom D. Ctnnb1 signaling in Sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS one. 2012, 7(1):e29764.
Laguë MN, Romieu-Mourez R, Bonneil E, Boyer A, Pouletty P, Mes-Masson AM, Thibault P, Nadeau ME, Boerboom D. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human
cancers. PLoS one. 2012, 7(8):e42470.
Richards JS, Fan HY, Liu Z, Tsoi M, Boyer A, Boerboom D. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis. Oncogene. 2012, 31(12):1504-20.
Boerboom D, Lafond JF, Zheng X, Lapointe E, Mittaz L, Boyer A, Pritchard M, DeMayo F, Mort J, Drolet R, Richards JS. Partially redundant function of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011, 240(7):1806-14.
Boyer A, Lapointe E, Zheng X, Cowan RG, Li H, Quirk SM, DeMayo FJ, Richards JS, Boerboom D. WNT4 is required for normal ovarian follicle development and female fertility. FASEB, 2010, 24(8):3010-25.
Boyer A, Goff AK, Boerboom D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol Metab. 2010, 21(1):25-32.
Laguë MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson L, Boerboom D. Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab, 2010. 299(6):E936-46.
Boyer A, Hermo L, Paquet M, Laguë MN, Boerboom D. Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis, 2009, 30(5): 869-78.
Boyer A, Hermo L, Paquet M, Robaire B, Boerboom D. Sustained activation of Wnt/β-catenin signaling in Sertoli cells causes seminiferous tubule degeneration and germ cell loss. Biology of Reproduction, 2008, 79(3):475-85.
Joubert P, Cordeau ME, Boyer A, Silversides DW, Lavoie JP. Cytokine expression by peripheral blood neutrophils from heaves-affected horses before and after allergen challenge. Vet J. 2008. 178(2):227-32.
Cory AT, Boyer A, Pilon N, Lussier J, Silversides DW. Presumptive pre-Sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in early testis differentiation. Mol Reprod Dev. 2007, 74(12):1491-504.
Boyer A, Pilon N, Raiwet D, Lussier JG, Silversides DW. Human and pig SRY 5’ flanking sequences can direct reporter transgene expression to the genital ridge and to the neural crest cells. Dev Dynamics, 2006, 235(3):623-32.
Boyer A, Lussier JG, Sinclair AH, McClive PJ, Silversides DW. Pre-Sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination. Biology of reproduction. 2004, 71(3): 820-7.
Boyer A, Paquet M, Raiwet D, Daneau I, Harrison W, Silversides DW. Rapid genomic identification of transgenic integration sites for mouse insertional mutants. Biotechniques. 2003, 34(1):32-4, 36.
Boyer A, Dornan S, Daneau I, Lussier JG, Silversides DW. Conservation of the function of DMRT1 regulatory sequences in mammalian sex differentiation. Genesis. 2002, 34(4):236-43.
Daneau I, Pilon N, Boyer A, Behdjani R, Overbeek PA, Viger R, Lussier JG, Silversides DW. The porcine SRY promoter is transactivated within a male genital ridge environment. Genesis. 2002, 33(4):170-80.
Silversides DW, Pilon N, Bedhjani R, Boyer A, Daneau I, Lussier JG. Genetic manipulation of sex differentiation and phenotype in domestic animals. Theriogenology. 2001, 55:51-63.
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