Derek Boerboom
- Professeur titulaire
-
Faculté de médecine vétérinaire - Département de biomédecine vétérinaire
Pavillon 3200, rue Sicotte - Aile A office 3453
Travail 1 : 450 773-8521 #0160
B.Sc.
1993
, Biochimie , McGill University (Canada)
M.Sc.
1995
, Biochimie , McGill University (Canada)
Ph.D.
2000
, Biologie moléculaire , Université de Montréal (Canada)
D.M.V.
2002
, Université de Montréal (Canada)
Études postdoctorales
2005
, Endocrinologie , Baylor College of Medicine (États-Unis)
Affiliations
Expertises
Student supervision Expand all Collapse all
Cycle : Master's
Grade : M. Sc.
Cycle : Doctoral
Grade : Ph. D.
Research projects Expand all Collapse all
Réseau Québécois en Reproduction Projet de recherche au Canada / 2024 - 2031
Regulation of gonadotropin action by Slit/Robo signaling in the mammalian orary Projet de recherche au Canada / 2018 - 2028
Role of development signaling pathways in testicular physiology and spermatogenesis Projet de recherche au Canada / 2017 - 2026
The Hippo pathway as a regulator of ovarian follicle development Projet de recherche au Canada / 2015 - 2026
Réseau Québecois en Reproduction (RQR) Projet de recherche au Canada / 2017 - 2025
Bourse de stage international - Melany Juarez / Réseau Québécois en reproduction (RQR) Projet de recherche au Canada / 2019 - 2022
Bourse de stage international - Jorge William Franco de Barros Jorge / Réseau Québécois en reproduction (RQR) Projet de recherche au Canada / 2019 - 2022
MECHANISMS OF GNRH ACTION Projet de recherche au Canada / 2014 - 2022
Supplément COVID-19 CRSNG_Role of development signaling pathways in testicular physiology and spermatogenesis Projet de recherche au Canada / 2020 - 2021
Bourse de stage international - Brocher Celia / Réseau Québécois en reproduction (RQR) Projet de recherche au Canada / 2018 - 2020
Bourse de stage international - Bienvenue-Pariseault Josianne / Réseau Québécois en reproduction (RQR) Projet de recherche au Canada / 2018 - 2020
Transcriptional regulation of follicle stimulating hormone synthesis Projet de recherche au Canada / 2014 - 2020
TRANSCRIPTIONAL REGULATION OF FOLLICLE STIMULATING HORMONE SYNTHESIS Projet de recherche au Canada / 2014 - 2020
Bourse de stage international - Yining Li - Regroupement stratégique Réseau Québécois en reproduction Projet de recherche au Canada / 2018 - 2019
Bourse de stage international - Raguema, Nozha, Regroupement stratégique Réseau Québécois en reproduction Projet de recherche au Canada / 2017 - 2019
ELUCIDATION OF THE ROLES OF WNT SIGNALING IN THE MAMMALIAN OVARY Projet de recherche au Canada / 2013 - 2019
BASIC RESEARCH EQUIPMENT AND LABORATORY SETUP FOR THE CANADA RESEARCH CHAIR IN OVARIAN MOLECULAR BIOLOGY AND FUNCTIONAL GENOMICS Projet de recherche au Canada / 2013 - 2019
ROLE OF DEVELOPMENTAL SIGNALING PATHWAYS IN TESTICULAR PHYSIOLOGY AND SPERMATOGENESIS Projet de recherche au Canada / 2012 - 2018
REGROUPEMENT STRATEGIQUE - RESEAU QUEBECOIS EN REPRODUCTION (RQR) Projet de recherche au Canada / 2011 - 2018
AMH, PREDICTIVE TOOL OF OVARIAN RESPONSE TO A SUPEROVULATION TREATMENT IN A COW Projet de recherche au Canada / 2014 - 2017
IMPORTANCE FONCTIONNELLE D'UNE DIVERGENCE EVOLUTIVE DE LA STRUCTURE DU RECEPTEUR DE LA GONADOLIBERINE CHEZ LES MAMMIFERES Projet de recherche au Canada / 2014 - 2017
IMPORTANCE FONCTIONNELLE D'UNE DIVERGENCE ÉVOLUTIVE DE LA STRUCTURE DU RÉCEPTEUR DE LA GONADOLIBÉRINE CHEZ LES MAMMIFÈRES Projet de recherche au Canada / 2013 - 2017
MECHANISMS OF GNRH ACTION Projet de recherche au Canada / 2012 - 2017
ASSESSEMENT OF VCP AS A POTENTIAL DIAGNOSTIC MARKER FOR EARLY-STAGE AND RECURRENT OVARIAN CANCER Projet de recherche au Canada / 2013 - 2016
BIOLOGIE MOLECULAIRE ET GENOMIQUE FONCTIONNELLE DE L'OVAIRE Projet de recherche au Canada / 2011 - 2016
Valosin containing protein (VCP): a novel therapeutic target for canine lymphoma Projet de recherche au Canada / 2013 - 2015
NOUVELLES VOIES VERS L'EMBRYON SAIN CHEZ LES ANIMAUX DE CONSOMMATION Projet de recherche au Canada / 2011 - 2015
TRAINING IN REPRODUCTIVE BIOLOGY Projet de recherche au Canada / 2009 - 2015
TRANSCRIPTIONAL REGULATION OF FOLLICLE STIMULATING HORMONE SYNTHESIS Projet de recherche au Canada / 2008 - 2014
TRANSCRIPTIONAL REGULATION OF FOLLICLE STIMULATING HORMONE SYNTHESIS Projet de recherche au Canada / 2008 - 2014
ELUCIDATION OF THE ROLES OF WNT SIGNALING IN THE MAMMALIAN OVARY Projet de recherche au Canada / 2009 - 2013
REMBOURSEMENT DU CONGÉ PARENTAL D'ÉVELYNE LAPOINTE Projet de recherche au Canada / 2011 - 2011
Publications Expand all Collapse all
Boyer A, Girard M, Thimmanahalli DS, Levasseur A, Celeste C, Paquet M, et al. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biology of reproduction. 2016;95(1):13. Epub 2016/06/10.
Abedini, A., Zamberlam, G., Lapointe, E., Tourigny, C., Boyer, A., Paquet, M., Hayashi, K., Honda, H., Kikuchi, A., Price, C.A. and Boerboom, D. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. The FASEB Journal Apr;30(4):1534-1547 (2016).
Abedini A, Zamberlam G, Boerboom D, Price CA. Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Molecular and cellular endocrinology. 2015;403:39-45. Epub 2015/01/21.
Boerboom D, Kumar V, Boyer A, Wang Y, Lambrot R, Zhou X, et al. beta-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015;156(1):323-33. Epub 2014/10/25.
Dong, Y., Wu, H., Rahman, H.N., Liu, Y., Pasula, S., Tessneer, K.L., Cai, X., Liu, X., Chang, B., McManus, J., Hahn, S., Dong, J., Brophy, M.L., Yu, L., Song, K., Silasi-Mansat, R., Saunders, D., Njoku, C., Song, H., Mehta-D'Souza, P., Towner, R., Lupu, F., McEver, R.P., Xia, L., Boerboom, D., Srinivasan, R.S., and Chen, H. Motif mimetic of epsin perturbs tumor growth and metastasis. Journal of Clinical Investigation Dec 1;125(12):4349-4364 (2015).
Nadeau, M.E., Rico, C., Tsoi, M., Vivancos, M., Filimon, S., Paquet, M. and Boerboom, D. Pharmacological targeting of valosin containing protein (VCP) selectively kills canine lymphoma cells by inducing DNA damage. BMC Cancer Jun 24;15:479 (2015).
Rico C, Dodelet-Devillers A, Paquet M, Tsoi M, Lapointe E, Carmeliet P, et al. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival in mice. Biology of reproduction. 2014;90(6):135. Epub 2014/05/24.
Tsoi M, Lague MN, Boyer A, Paquet M, Nadeau ME, Boerboom D. Anti-VEGFA Therapy Reduces Tumor Growth and Extends Survival in a Murine Model of Ovarian Granulosa Cell Tumor. Translational oncology. 2013;6(3):226-33. Epub 2013/06/05.
Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, et al. Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Molecular endocrinology (Baltimore, Md). 2013;27(3):407-21. Epub 2013/01/24.
Fortin J, Kumar V, Zhou X, Wang Y, Auwerx J, Schoonjans K, et al. NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. PloS one. 2013;8(3):e59058. Epub 2013/03/29.
Lapointe E, Boyer A, Rico C, Paquet M, Franco HL, Gossen J, et al. FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biology of reproduction. 2012;87(5):104. Epub 2012/09/08.
Rico C, Lague MN, Lefevre P, Tsoi M, Dodelet-Devillers A, Kumar V, et al. Pharmacological targeting of mammalian target of rapamycin inhibits ovarian granulosa cell tumor growth. Carcinogenesis. 2012;33(11):2283-92. Epub 2012/08/09.
Richards JS, Fan HY, Liu Z, Tsoi M, Lague MN, Boyer A, et al. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012;31(12):1504-20. Epub 2011/08/24.
Lague MN, Romieu-Mourez R, Bonneil E, Boyer A, Pouletty N, Mes-Masson AM, et al. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. PloS one. 2012;7(8):e42470. Epub 2012/08/08.
Deschene K, Celeste C, Boerboom D, Theoret CL. Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1. Journal of dermatological science. 2012;65(1):12-8. Epub 2011/10/18.
Boyer A, Yeh JR, Zhang X, Paquet M, Gaudin A, Nagano MC, et al. CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4. PloS one. 2012;7(1):e29764. Epub 2012/01/19.
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