Julie Brind'Amour
Courriels
julie.brindamour@umontreal.ca (Travail)
Travail 1 : 450 773-8521 #12984
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Affiliations
Expertises
Research projects Expand all Collapse all
Heterochromatin Protein 1 (HP1) in maternal infertility and embryonic development Projet de recherche au Canada / 2023 - 2030
Explore the relationship between the subcortical maternal complex (SCMC) and epigenetic remodeling during oogenesis and early embryogenesis Projet de recherche au Canada / 2023 - 2029
Explore the relationship between the subcortical maternal complex (SCMC) and epigenetic remodeling during oogenesis and early embryogenesis Projet de recherche au Canada / 2023 - 2029
Transcriptional Regulation of Human Trophoblast Development Projet de recherche au Canada / 2023 - 2026
Identification of early markers of epigenetic disorders in bovine production Projet de recherche au Canada / 2023 - 2026
Identification of early markers of developmental epigenetic anomalies in bovine production Projet de recherche au Canada / 2023 - 2026
Identification of early markers of developmental epigenetic anomalies in bovine production Projet de recherche au Canada / 2022 - 2023
Publications Expand all Collapse all
Publications connexes:
*Bogutz AB, *Brind’Amour J, *Kobayashi H, Jensen KN, Nakabayashi K, Imai H, Lorincz MC#, and Lefebvre L#. Endogenous retroviruses direct the evolution of lineage-specific imprinting. Nature Commun. 2019. Dec 12;10(1):5674 *equal contribution
Brind’Amour J, Kobayashi H, Richard Albert J, Shirane K, Sakashita A, Kamio A, Bogutz A, Koike T, Karimi M.M, Lefebvre L.L, Kono T and Lorincz M.C. LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation. Nature Commun. 2018. Aug 20;9(1):3331
Brind'Amour J, Liu S, Hudson M, Chen C, Karimi MM, Lorincz MC. An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations. Nat Commun. 2015. Jan 21;6:6033.
*Liu S, *Brind'Amour J, Karimi MM, Shirane K, Bogutz A, Lefebvre L, Sasaki H, Shinkai Y, Lorincz MC. Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells. Genes Dev. 2014. Sep 15;28(18):2041-55. *equal contribution.
Commentaires:
Brind’Amour J and Lorincz MC. Setting the chromatin stage in oocytes. Nature Cell Biology. 2020. March 30. News and Views.
Brind'Amour J, Mager DL. Reality check for transposon enhancers. Elife. 2019. May 31. Highlight.
Contributions & collaborations:
Lismer A, Lafleur C, Siklenka K, Lambrot R, Brind’Amour J, Lorincz MC, Dumeaux V, Kimmins S. Paternal folate deficiency induces aberrant sperm histone H3 lysine 4 trimethylation which is transmitted to the embryo. Dev Cell. 2021 Mar 8;56(5):671-686.
Richard Albert J, Au Yeung WK, Toriyama K, Kobayashi H, Hirasawa R, Brind'Amour J, Bogutz AB, Sasaki H & Lorincz MC. Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo. Nature Commun. 2020. Oct 27; 11(5417)
Hu CK, *Wang W, *Brind’Amour J, Singh PP, Reeves GA, Lorincz MC, Sánchez Alvarado A, and Brunet A. Vertebrate diapause preserves organisms long-term via Polycomb complex members. Science. 2020. Feb 21;367(6480):870-874. *equal contribution
Qianhua Xu*, Yunlong Xiang*, Qiujun Wang*, Leyun Wang*, Julie Brind’Amour, Aaron Blair Bogutz, Yu Zhang, Bingjie Zhang, Guang Yu, Weikun Xia, Zhenhai Du, Chunyi Huang, Jing Ma, Hui Zheng, Yuanyuan Li, Chao Liu, Cheryl Lyn Walker, Eric Jonasch, Louis Lefebvre, Min Wu, Matthew Lorincz, Wei Li#, Li Li#, Wei Xie#. SETD2 regulates maternal epigenomic reprogramming and fertility. Nature Genetics. 2019. April 29. *equal contribution
Au Yeung WK, Brind’Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, and Sasaki H. Histone H3K9 methyltransferase G9a in oocyte is essential for preimplantation development but dispensable for CG demethylation protection. Cell Rep. 2019. Apr 2;27(1):282-293.e4
Communications Expand all Collapse all
Présentations invitées:
2021 Fragile Nucleosome Seminar Series. Online seminar (international audience). “Maternally-inherited H3K27me3 inhibits enhancer commissioning and transcription in the early embryo.”
2019 CEEHRC/IHEC meeting (emergent researcher award). Banff, Canada. “Interplay between histone modifications and DNA methylation during oocyte development.”
2019 Alberta Children’s Hospital Research Institute. Calgary, Canada. “Interplay between transcription, histone modifications and DNA methylation during oogenesis and development.”
2019 Centre de Recherche en Reproduction et Fertilité (CRRF). Saint-Hyacinthe, Canada. “Impact of transcription on the establishment of the maternal epigenome.”
2019 Life Sciences Institute (LSI), University of British Columbia. Vancouver, Canada. “Interplay between histone modifications and DNA methylation during development.”
2018 Centre for Research in Reproduction and Development (CRRD), McGill University, Montreal, Canada. “Species-specific endogenous retroviruses drive widespread and heritable DNA methylation changes in oocytes.”
2016 39th Annual Meeting. Molecular Biology Society of Japan, Yokohama, Japan. “Impact of maternally inherited histone modifications on DNA methylation maintenance and enhancer activation in the early embryo.”
2016 Canadian Fertility and Andrology Society (CFAS) Workshop, Vancouver, Canada. “Maternal epigenetic contribution to the early embryo.”
2015 Stem Cell Network (SCN) OMICS Workshop, Toronto, Canada. “Ultra-low-input ChIP-seq for rare cell populations: expectations and realities.”
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