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Levon Abrahamyan

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Professeur agrégé

Faculté de médecine vétérinaire - Département de pathologie et microbiologie

Pavillon 3200, rue Sicotte - Aile A office 3909

Courriels

levon.abrahamyan@umontreal.ca (Travail)

Travail 1 : 450 773-8521 #29536

B.Sc.
1984 , Biologie et autres sciences connexes , Institute of General Genetics, Yerevan State University (Russie (Fédération de))

M.Sc.
1986 , Génétique , Institute of General Genetics, Yerevan State University (Russie (Fédération de))

Ph.D.
1990 , Génétique , Institute of General Genetics, Yerevan State University (Russie (Fédération de))

D. Sc.
1995 , Génétique , Institute of Molecular Genetics, Russian Academy of Sciences (Russie (Fédération de))

Affiliations

Education Programs

  • Health Sciences

Courses

  • DMV1220 Microbiologie vétérinaire
  • MMV70001 Ateliers de recherche 1
  • MMV70002 Ateliers de recherche 2
  • MMV70003 Ateliers de recherche 3
  • MMV70004 Ateliers de recherche 4
  • MMV70005 Ateliers de recherche 5
  • PTM6677 Ateliers de recherche

Expertises

The long-term goal of my research program is to better understand molecular mechanisms of interactions between animal viruses and their hosts in order to develop new strategies for effective control of viral infections. In my laboratory, we study molecular mechanisms of virus-host interactions of different viruses: the porcine reproductive and respiratory syndrome virus (PRRSV), the porcine epidemic diarrhea virus (PEDV, a coronavirus), the Aleutian mink disease virus (AMDV, a parvovirus), the porcine influenza virus, various arboviruses (Zika, dengue, etc.). Additionally, we are interested in studying viral pathogens that infect the honeybees (virome studies). Host-virus interactions are highly dynamic and may involve multiprotein complexes. My group is using cutting-edge molecular biology, microscopy, proteomics, classical and molecular virology approaches to decipher the interplay of the key molecular factors of the virus infection that contribute to the unique pathogenesis of the animal viruses that are  important for human and animal health. I believe that science popularization plays an important role in enhancing public service, promotes scientific literacy and awareness of global health. 

Student supervision Expand all Collapse all

Decoding protein networks during porcine reproductive and respiratory syndrome virus infection through proteomics Thèses et mémoires dirigés / 2021 - 2021
Graduate : Sanchez Mendoza, Laura
Cycle : Master's
Grade : M. Sc.
Decoding protein networks during porcine epidemic diarrhea virus (PEDV) infection through proteomics Thèses et mémoires dirigés / 2019 - 2019
Graduate : Valle-Tejada, Camila Andrea
Cycle : Master's
Grade : M. Sc.

Research projects Expand all Collapse all

Appui au Centre de recherche en infectiologie porcine et avicole (CRIPA) Projet de recherche au Canada / 2022 - 2029

Lead researcher : Mariela Segura
Co-researchers : Martine Boulianne , John Morris Fairbrother , Marcelo Gottschalk , France Daigle , Jean-Pierre Vaillancourt , Carl A. Gagnon , Francis Beaudry , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Marie-Lou Gaucher , Alexandre Thibodeau , Mohamed Rhouma , Imourana Alassane-Kpembi , Nahuel Fittipaldi , François Malouin , Sebastien Faucher , Charles Dozois , Xin Zhao , Denis Archambault , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Jennifer Ronholm , George Saji , Martin Olivier , Michel Frenette , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy , Sébastien Fournel , Maurice Doyon , Shiv O Prasher , Paul Thomassin , Linda Saucier , Vincent Burrus , Jonathan Perreault , Marie-Joelle Brassard , Jamie Dallaire , Charles Gauthier , Antony Vincent
Funding sources: EVAH
Grant programs:

Centre de Recherche en Infectiologie Porcine et Avicole (CRIPA) Projet de recherche au Canada / 2022 - 2029

Lead researcher : Mariela Segura
Co-researchers : Martine Boulianne , John Morris Fairbrother , Marcelo Gottschalk , France Daigle , Jean-Pierre Vaillancourt , Carl A. Gagnon , Francis Beaudry , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Marie-Lou Gaucher , Alexandre Thibodeau , Mohamed Rhouma , Imourana Alassane-Kpembi , Nahuel Fittipaldi , François Malouin , Sebastien Faucher , Charles Dozois , Xin Zhao , Denis Archambault , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Jennifer Ronholm , George Saji , Martin Olivier , Michel Frenette , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy , Sébastien Fournel , Maurice Doyon , Shiv O Prasher , Paul Thomassin , Linda Saucier , Vincent Burrus , Jonathan Perreault , Marie-Joelle Brassard , Jamie Dallaire , Charles Gauthier , Antony Vincent , Alexander Bekele-Yitbarek
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques

Appui au Centre de recherche en infectiologie porcine et avicole (CRIPA) Projet de recherche au Canada / 2022 - 2029

Lead researcher : Mariela Segura
Co-researchers : Martine Boulianne , John Morris Fairbrother , Marcelo Gottschalk , France Daigle , Jean-Pierre Vaillancourt , Carl A. Gagnon , Francis Beaudry , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Marie-Lou Gaucher , Alexandre Thibodeau , Mohamed Rhouma , Imourana Alassane-Kpembi , Nahuel Fittipaldi , François Malouin , Sebastien Faucher , Charles Dozois , Xin Zhao , Denis Archambault , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Jennifer Ronholm , George Saji , Martin Olivier , Michel Frenette , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy , Sébastien Fournel , Maurice Doyon , Shiv O Prasher , Paul Thomassin , Linda Saucier , Vincent Burrus , Jonathan Perreault , Marie-Joelle Brassard , Jamie Dallaire , Charles Gauthier , Antony Vincent
Funding sources: Fédération des producteurs d'oeufs du Québec
Grant programs:

Appui au Centre de recherche en infectiologie porcine et avicole (CRIPA) Projet de recherche au Canada / 2022 - 2029

Lead researcher : Mariela Segura
Co-researchers : Martine Boulianne , John Morris Fairbrother , Marcelo Gottschalk , France Daigle , Jean-Pierre Vaillancourt , Carl A. Gagnon , Francis Beaudry , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Marie-Lou Gaucher , Alexandre Thibodeau , Mohamed Rhouma , Imourana Alassane-Kpembi , Nahuel Fittipaldi , François Malouin , Sebastien Faucher , Charles Dozois , Xin Zhao , Denis Archambault , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Jennifer Ronholm , George Saji , Martin Olivier , Michel Frenette , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy , Sébastien Fournel , Maurice Doyon , Shiv O Prasher , Paul Thomassin , Linda Saucier , Vincent Burrus , Jonathan Perreault , Marie-Joelle Brassard , Jamie Dallaire , Charles Gauthier , Antony Vincent
Funding sources: PORCIMA
Grant programs:

Appui au Centre de recherche en infectiologie porcine et avicole (CRIPA) Projet de recherche au Canada / 2022 - 2029

Lead researcher : Mariela Segura
Co-researchers : Martine Boulianne , John Morris Fairbrother , Marcelo Gottschalk , France Daigle , Jean-Pierre Vaillancourt , Carl A. Gagnon , Francis Beaudry , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Marie-Lou Gaucher , Alexandre Thibodeau , Mohamed Rhouma , Imourana Alassane-Kpembi , Nahuel Fittipaldi , François Malouin , Sebastien Faucher , Charles Dozois , Xin Zhao , Denis Archambault , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Jennifer Ronholm , George Saji , Martin Olivier , Michel Frenette , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy , Sébastien Fournel , Maurice Doyon , Shiv O Prasher , Paul Thomassin , Linda Saucier , Vincent Burrus , Jonathan Perreault , Marie-Joelle Brassard , Jamie Dallaire , Charles Gauthier , Antony Vincent
Funding sources: Producteurs d'œufs d'incubation du Qc
Grant programs:

Nouvelles Initiatives du CRIPA en partenariat avec IRSST Projet de recherche au Canada / 2022 - 2025

Lead researcher : Mariela Segura
Co-researchers : Martine Boulianne , John Morris Fairbrother , Marcelo Gottschalk , France Daigle , Jean-Pierre Vaillancourt , Carl A. Gagnon , Francis Beaudry , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Marie-Lou Gaucher , Alexandre Thibodeau , Mohamed Rhouma , Imourana Alassane-Kpembi , Nahuel Fittipaldi , François Malouin , Sebastien Faucher , Charles Dozois , Xin Zhao , Denis Archambault , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Jennifer Ronholm , George Saji , Martin Olivier , Michel Frenette , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy , Sébastien Fournel , Maurice Doyon , Shiv O Prasher , Paul Thomassin , Linda Saucier , Vincent Burrus , Jonathan Perreault , Marie-Joelle Brassard , Jamie Dallaire , Charles Gauthier , Antony Vincent
Funding sources: IRSST/Institut de recherche Robert-Sauvé en santé et en sécurité du travail
Grant programs: PVXXXXXX-Programme de recherche

Appui au Centre de recherche en infectiologie porcine et avicole (CRIPA) Projet de recherche au Canada / 2022 - 2025

Funding sources: Municipalité régionale de comté des Maskoutains
Grant programs:

Identification des interactions moléculaires hôte-pathogène par une approche systémique renforcée par la microscopie à super-résolution Projet de recherche au Canada / 2022 - 2025

Lead researcher : Levon Abrahamyan
Funding sources: FCI/Fondation canadienne pour l'innovation
Grant programs: PVXXXXXX-Fonds des leaders

Studies on Molecular Mechanisms of HostPathogen Interactions of Nidoviruses of Veterinary Importance Projet de recherche au Canada / 2017 - 2024

Lead researcher : Levon Abrahamyan
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe

Acquisition of an ultracentrifuge to support research in the field of veterinary infectious diseases Projet de recherche au Canada / 2021 - 2023

Lead researcher : Carl A. Gagnon
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (de 7 001 $ à 150 000 $)

Centre de Recherche en infectiologie porcine et avicole (CRIPA) / Regroupements stratégiques Projet de recherche au Canada / 2019 - 2023

Lead researcher : Carl A. Gagnon , Mariela Segura
Co-researchers : Martine Boulianne , Daniel Dubreuil , John Morris Fairbrother , Josée Harel , Marcelo Gottschalk , France Daigle , Sylvie D'Allaire , Jean-Pierre Vaillancourt , Francis Beaudry , Philippe Fravalo , Marie Archambault , Nancy Beauregard , Julie Arsenault , Younès Chorfi , Yvan L'Homme , Marie-Odile Benoit-Biancamano , Levon Abrahamyan , Christopher Fernandez Prada , Marcio Costa , Marie-Ève Lambert , Neda Barjesteh , Hélène Carabin , François Malouin , Lawrence Goodridge , Sebastien Faucher , Charles Dozois , Xin Zhao , Daniel Grenier , Denis Archambault , Frédéric Guay , René Roy , Caroline Duchaine , Steve Charette , Mircea A. Mateescu , Steve Bourgault , Mohammad-Ali Jenabian , Jennifer Ronholm , Étienne Yergeau , George Saji , Martin Olivier , Michel Frenette , Nadia Bergeron , Jean-Philippe Rocheleau , Marie-Pierre Létourneau-Montminy
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques

Studies on Molecular Mechanisms of HostPathogen Interactions of Nidoviruses of Veterinary Importance Projet de recherche au Canada / 2017 - 2022

Lead researcher : Levon Abrahamyan

The proposed program will advance fundamental knowledge about the molecular
mechanisms of virus-host interactions of important animal RNA viruses united in the Nidovirales
order. The porcine reproductive and respiratory syndrome virus (PRRSV) and the porcine
epidemic diarrhea virus (PEDV) are nidoviruses responsible for severe agricultural economic losses
and considered to be the primary emerging livestock pathogens in Canada and globally. Although
the hosts have developed multiple immune defense systems that could fend off viral infections and
control viral disease, viruses have evolved to invade host cells and hijack the host cellular machinery
in order to survive and replicate. Thus, understanding how viruses attach and enter target cells, how
viruses establish a fine-tuned balance between host and virus genome translation, how viruses traffic
their genomes and proteins to the sites of virions assembly, and modulate host innate response, will
uncover novel targets for antiviral therapies and control viral spread.

Development of Next Generation Vaccine for Aleutian Disease in mink Projet de recherche au Canada / 2018 - 2021

Lead researcher : Levon Abrahamyan
Co-researchers : Mariela Segura , Farid Hossain
Funding sources: Canada Mink Breeders Association
Grant programs:

Amélioration des services de génomique en infectiologie animale et de la banque de données centralisées des séquences québécoises du virus du syndrome reproducteur et respiratoire porcin (BCSQ) Projet de recherche au Canada / 2016 - 2021

Lead researcher : Carl A. Gagnon
Co-researchers : Levon Abrahamyan
Funding sources: MAPAQ/Ministère de l'Agriculture, des Pêcheries et de l'Alimentation
Grant programs:

Acquisition of a highspeed highvolume floor centrifuge to support research in the field of veterinary infectious diseases Projet de recherche au Canada / 2017 - 2019

Lead researcher : Carl A. Gagnon
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (de 7 001 $ à 150 000 $)

Publications Expand all Collapse all

Markarian, N.M.; Galli, G.; Patel, D.; Hemmings, M.; Nagpal, P.; Berghuis, A.M.; Abrahamyan, L.* and Vidal, S.M*. Identifying Markers of Emerging SARS-CoV-2 Variants in Patients with Secondary Immunodeficiency. Frontiers in Microbiology, 2022. doi: 10.3389/fmicb.2022.93398. *Equally contributed co-corresponding authors

Vázquez-Valadez, V.H., Hernández-Serda, A., Jiménez-Cabiedes, M.F., Aguirre-Vidal, P., González-Tapia, I., Carreño-Varga,s L., Alarcón-López, Y.A., Espejel-Fuentes, A., Martínez-Soriano, P., Lugo Álvarez., M., Velázquez -Sánchez A.M., Markarian, N.M., Angeles, E., and L. Abrahamyan*. Evaluation of inhibitory activity in silico of in house thiomorpholine compounds between the ACE2 receptor and S1 subunit of SARS-CoV-2 spike. Pathogens, 2021 Sep 17;10(9):1208. doi: 10.3390/pathogens10091208. Impact Factor 4.066. *Corresponding author

Markarian N.M. and L. Abrahamyan*. AMDV Vaccine: Challenges and Perspectives. Viruses, 2021; 13(9):1833. https://doi.org/10.3390/v13091833. Impact Factor 5.127. *Corresponding author

Zakharova O.I.*, Titov I.A., Gogin A.E., Sevskikh T.A., Korennoy F.I., Kolbasov D.V., Abrahamyan, L.* and A. Blokhin. African Swine Fever in the Russian Far East (2019-2020): Spatio-Temporal Analysis and Implications for Wild Ungulates. Frontiers in Veterinary Science, 2021. 8:882; doi: 10.3389/fvets.2021.723081. Impact Factor 3.412. *Co-corresponding authors.

Dai X., Zhang X., Ostrikov K., and Abrahamyan L. Host receptors: the key to establishing cells with broad viral tropism for vaccine production. Critical Reviews in Microbiology, 2020 Mar; 46(2):147-168; doi: 10.1080/1040841X.2020.1735992.2020. Impact Factor 8.641.

Couture É.L., Ferrell S.T., Desmarchelier M., Hamelin M.È., Sánchez Mendoza L.J., Carbonneau J., Abrahamyan L., Boivin G., Lair S. Human parainfluenza 2 related illness and a death in a group of captive western lowland gorillas (Gorilla gorilla gorilla). J Zoo Wildl Med., 2019 Sep;50(3):713-717; doi: 10.1638/2018-0237. Impact Factor 0.776.

Soldatova, I., T. Prilepskaja, L. Abrahamyan, J. Forstová and S. Huérfano. Interaction of the mouse polyomavirus capsid proteins with importins is required for efficient import of viral DNA into the cell nucleus. Viruses, 2018, 10(4), 165; doi:10.3390/v10040165. This paper was highlighted by the editors and one of the images served as a cover page. Impact Factor 5.127.

Churbanov*, A. and L. Abrahamyan*. Preventing common hereditary disorders through time separated twinning. Special Issue: Molecular and Regenerative Medicine. BioNanoScience (Springer), March 2018, Volume 8, Issue 1, pp 344–366; doi: 10.1007/s12668-017-0488-x. *Co-corresponding authors.

Agafonova*, E.V., F.F. Rizvanova, A.E. Kadyrova, and L. Abrahamyan*. Regulatory profile changes of lymphocytes and peripheral blood monocytes in children with candidiasis associated with chronic somatic diseases. Special Issue: Molecular Pathology of Infectious and Autoimmune Diseases. BioNanoScience (Springer) 7:1-6, 2017; doi: 10.1007/s12668-017-0430-2. *Co-corresponding authors.

Khaertynov*, Kh.S., V.A. Anokhin, Y.N. Davidyuk, I.V. Nicolaeva, S.V. Khalioullina, D.R. Semenova, E.Y. Alatyrev, N.N. Skvortsova, and L.G. Abrahamyan*. Case of meningitis in a neonate caused by an extended-spectrum-beta-lactamase-producing strain of hypervirulent Klebsiella pneumoniae. Frontiers in Microbiology, 2017. doi: 10.3389/fmicb.2017.01576. Impact Factor 5.640. *Co-corresponding authors.

Wang, C., H. Meng, Y. Gao, H. Gao, K. Guo, F. Almazan, I. Sola, L. Enjuanes, Y. Zhang*, et L. Abrahamyan*. Role of transcription regulatory sequence in regulation of gene expression and replication of porcine reproductive and respiratory syndrome virus. Veterinary Research, 48:41, 2017. doi: 10.1186/s13567-017-0445-2. Impact Factor 4.106. *Co-corresponding authors.

Morzunov, S., Deyde, V., and L. Abrahamyan. New Biomarkers of Innate and Adaptive Immunity in Infectious Diseases. Editorial review. Journal of Immunology Research, September volume, 2017; 2017:7047405. doi: 10.1155/2017/7047405. Guest Editor of Special Issue. Impact Factor 4.818.

Gagnon, C.A., C.K. Traesel, N. Music, J. Laroche, N. Tison, J-P. Auger, S. Music, C. Provost, C. Bellehumeur, L. Abrahamyan, S. Carman, L. DesCôteaux, and S.J. Charette. Whole genome sequencing of a Canadian bovine gammaherpesvirus 4 strain and the possible link between the viral infection and respiratory and reproductive clinical manifestations in dairy cattle. Frontiers in Veterinary Science, 4:92, 2017; doi: 10.3389/fvets.2017.00092. Impact Factor 3.412.

Bilkova, E., J. Forstova, L. Abrahamyan*. 2014. Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking. Viruses 6 (7):2899-2937. Impact Factor 5.127. *Corresponding author

Tso, F. Y., L. Abrahamyan, S. L. Hu, R. M. Ruprecht, C. Wood. 2013. Variations in the biological functions of HIV-1 clade C envelope in a SHIV-infected Rhesus macaque during disease progression. Plos One 8 (6):e66973.

Bohl, C., D. Bowder, J. Thompson, L. Abrahamyan, S. Gonzalez-Ramirez, Y. Mao, J. Sodroski, C. Wood, S. H. Xiang. 2013. A twin-cysteine motif in the V2 region of gp120 is associated with SIV envelope trimer stabilization. Plos One 8 (7):e69406.

Bohl, C. R., L. G. Abrahamyan, C. Wood. 2013. Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner. Plos One 8 (7):e69359.

Guo, H., L. G. Abrahamyan, C. Liu, M. Waltke, Y. Geng, Q. Chen, C. Wood, X. Kong. 2012. Comparative analysis of the fusion efficiency elicited by the envelope glycoprotein V1-V5 regions derived from human immunodeficiency virus type 1 transmitted perinatally. Journal of General Virology 93 (Pt 12):2635-2645.                                                                 

Belzile*, J. P., L. G. Abrahamyan*, F. C. Gerard, N. Rougeau, E. A. Cohen. 2010. Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest. PLoS Pathog 6 (9):e1001080. *Equal contribution. One of the images was published on the cover page of the journal.

Abrahamyan, L. G., L. Chatel-Chaix, L. Ajamian, M. P. Milev, A. Monette, J. F. Clement, R. Song, M. Lehmann, L. DesGroseillers, M. Laughrea, G. Boccaccio, A. J. Mouland. 2010. Novel Staufen1 ribonucleoproteins prevent formation of stress granules, but favour encapsidation of HIV-1 genomic RNA. Journal of Cell Science 123 (Pt 3):369-383.

Lehmann, M., M. P. Milev, L. Abrahamyan, X. J. Yao, N. Pante, A. J. Mouland. 2009. Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning. Journal of Biological Chemistry 284 (21):14572-14585.

Ajamian*, L., L. Abrahamyan*, M. Milev, P. V. Ivanov, A. E. Kulozik, N. H. Gehring, 
A. J. Mouland. 2008. Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation. RNA 14 (5):914-927. *Equal contribution

Kafaie, J., R. Song, L. Abrahamyan, A. J. Mouland, M. Laughrea. 2008. Mapping of nucleocapsid residues important for HIV-1 genomic RNA dimerization and packaging. Virology 375 (2):592-610.

Ma, J., L. Rong, Y. Zhou, B. B. Roy, J. Lu, L. Abrahamyan, A. J. Mouland, Q. Pan, C. Liang. 2008. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. Virology 375 (1):253-264.

Chatel-Chaix, L., L. Abrahamyan, C. Frechina, A. J. Mouland, L. DesGroseillers. 2007. The host protein Staufen1 participates in human immunodeficiency virus type 1 assembly in live cells by influencing pr55Gag multimerization. Journal of Virology 81 (12):6216-6230.

Levesque*, K., M. Halvorsen*, L. Abrahamyan, L. Chatel-Chaix, V. Poupon, H. Gordon,
L. DesGroseillers, A. Gatignol, A. J. Mouland. 2006. Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly. Traffic 7 (9):1177-1193. *Equal contribution

Hu, K., J. F. Clement, L. Abrahamyan, K. Strebel, M. Bouvier, L. Kleiman, A. J. Mouland. 2005. A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer. Journal of Virological Methods 128 (1-2):93-103.

Melikyan, G. B., R. J. Barnard, L. G. Abrahamyan, W. Mothes, J. A. Young. 2005. Imaging individual retroviral fusion events: from hemifusion to pore formation and growth. Proceedings of the National Academy of Sciences of the United States of America 102 (24):8728-8733.

Abrahamyan, L. G., S. R. Mkrtchyan, J. Binley, M. Lu, G. B. Melikyan, F. S. Cohen. 2005. The cytoplasmic tail slows the folding of human immunodeficiency virus type 1 Env from a late prebundle configuration into the six-helix bundle. Journal of Virology 79 (1):106-115.

Abrahamyan, L. G., R. M. Markosyan, J. P. Moore, F. S. Cohen, G. B. Melikyan. 2003. Human immunodeficiency virus type 1 Env with an intersubunit disulfide bond engages coreceptors but requires bond reduction after engagement to induce fusion. Journal of Virology 77 (10):5829-5836.

Abramian, L.G., E.S. Tsymbalyuk, T.G. Gazaryan, I.V. Levchenko, N.B. Andreeva,
K.G. Gazaryan. 1996. Expression of gene for homoserine kinase of Escherichia coli in mammalian cells. Molecular Biology. Plenum Publishing Corporation, NY, Vol.30, No.4, p.1, pp 494-498.

Abramian, L.G., I.R. Arkhipova, N.S. Ambartsumyan.1993. Long terminal repeats of Drosophila mobile elements direct transcription in E.coli cells. Molecular Biology, Plenum Publishing Corporation, NY, V. 27, No 2, p.2, pp. 217-219.

Abrahamian, L.G., R.M. Arutyunyan, T.F. Sarkisian, G.D. Zasukhina, S.B. Seredenin, A.D. Durnev. 1990. The complex study of the modification of action of chemical mutagens in human lymphocytes cultures. Biological Journal of Armenia, V. 43, N9, p. 733-738

Arutyunyan, R.M., N.R. Kochar, S.A. Chavushyan, A.A. Kazaryan, L.G. Abrahamian, A.G. Kirakosyan. 1988. The anthropogenetic study of origin from the region of historical Armenia-Sasun.  Biological Journal of Armenia, V. XLI, N9, P.723-728.

Kochar, N.R., R.M. Arutyunyan, S.A. Chavushyan, L.G. Abrahamian, A.A. Kazaryan, K.Yu. Martirosyan. 1988. The anthropogenetic study of origin from the region of historical Armenia-Alashkert. Biological Journal of Armenia, V. XLI, N9, P. 728 - 731.

Communications Expand all Collapse all

https://globalnews.ca/video/rd/3f010f7e-4eb1-11ea-9208-0242ac110002/?jwsource=cl

https://www.lapresse.ca/covid-19/2020-04-08/la-covid-19-transmissible-aux-animaux

https://montrealgazette.com/news/local-news/international-students-study-honey-bee-viruses-with-quebec-scientists

https://montreal.citynews.ca/video/2020/02/17/quebec-research-into-coronavirus/

https://www.tvanouvelles.ca/videos/6151825880001

https://horizonweekly.ca/en/interview-with-canadian-armenian-virologist-dr-levon-abrahamyan-its-important-for-armenia-to-take-the-advice-of-the-experts-who-already-experienced-the-crisis-in-their-country/

https://nrbhss.ca/sites/default/files/covid19/20200420_Breifing_notes_SARS_CoV_2_Animals_and_%20food.pdf

https://www.lecourrier.qc.ca/la-faculte-de-medecine-veterinaire-un-maillon-essentiel/

https://ici.radio-canada.ca/premiere/emissions/d-est-en-est/segments/entrevue/127653/abeilles-declin-ecatombe-pesticides-virus-medecine-veterinaire-levon-abrahamyan

https://ici.radio-canada.ca/nouvelle/1241923/abeilles-parasite-varros-destructor-virus-abrahamyan-marbaix

https://www.mitacs.ca/en/impact/counteracting-colony-collapse-research-team-seeks-solve-honeybee-mystery

https://plus.lapresse.ca/screens/c20a8ec0-ef9c-49f5-80d2-981037d34db9__7C___0.html

http://alaorilladelrio.com/2020/03/23/aun-estamos-a-tiempo-de-evitar-la-tragedia-entrevista-con-el-biologo-levon-abrahamyan/

https://www.thesuburban.com/life/education/hundreds-of-world-s-brightest-young-minds-spending-summer-in/article_8f721982-ab4e-11e9-b221-d34f0edef949.html

https://globalnews.ca/news/7358296/coronavirus-covid-19-mutation-transmit-infect-study/

https://ici.radio-canada.ca/premiere/emissions/les-annees-lumiere/segments/reportage/155110/coronavirus-virus-chauve-souris-pangolin-transmission?fbclid=IwAR1MgiB_ycA_Hw_On7vjWuthG48znRll-B1TZq1gEIcdce-6v7EMiS4tb1k

https://www.cbc.ca/listen/live-radio/1-383-lets-go/clip/15769070-virology-bats-and-covid-19?share=true

Additional Information

  • Le Centre de recherche en infectiologie porcine et avicole (CRIPA)
    Le Centre de recherche en infectiologie porcine et avicole (CRIPA) vous souhaite la bienvenue. Ce centre est situé à la Faculté de médecine vétérinaire de l’Université de Montréal.
  • Le Groupe de recherche sur les maladies infectieuses en production animale (GREMIP)
    Les travaux de recherche des membres du GREMIP portent principalement sur la pathogénie des infections bactériennes et virales animales. En mai 2016, le GREMIP a reçu le Prix du recteur catégorie Collaboration de l'Université de Montréal. Ce prix récompense une équipe qui, par la cohésion de ses membres et les efforts de chacun fait preuve d’une performance exceptionnelle dans l’atteinte d’un objectif commun ou dans la réussite d’un projet.
  • Le Groupe de recherche en épidémiologie des zoonoses et santé publique (GREZOSP)
    Le Groupe de recherche en épidémiologie des zoonoses et santé publique (GREZOSP) est un rassemblement de chercheurs et d’organisations dont la mission est de promouvoir la recherche sur des problématiques de santé publique et de santé animale au niveau des populations afin d’orienter les actions collectives et les politiques publiques.

Media

Levon Abrahamyan, professeur en virologie à la FMV, commente la campagne de vaccination en cours

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