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Julie Brind'Amour

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Professeure adjointe

Faculté de médecine vétérinaire - Département de biomédecine vétérinaire

Courriels

julie.brindamour@umontreal.ca (Travail)

Travail 1 : 450 773-8521 #12984

Web : ResearchGate

Web : LinkedIn

Web : Google Scholar

Affiliations

  • Membre – CRRF — Centre de recherche en reproduction et fertilité
  • Membre – CERCL — Centre d’expertise et de recherche clinique en santé et bien être animal

Education Programs

  • Health Sciences
  • Health Sciences
  • Health Sciences

Courses

  • MMV6670 Communication scientifique vétérinaire

Expertises

  • Animal Reproduction
  • Molecular biology
  • Genetics

Research projects Expand all Collapse all

Réseau Québécois en Reproduction Projet de recherche au Canada / 2024 - 2031

Lead researcher : Derek Boerboom , Jocelyn Dubuc
Co-researchers : Lawrence C. Smith , Bruce D. Murphy , Christopher A. Price , Jacques Drouin , André Tremblay , Jean-Claude Labbé , Julie Lavoie , Sébastien Buczinski , Simon Dufour , Greg Fitzharris , Alexandre Boyer , Kalidou Ndiaye , Serge McGraw , Mouhamadou Diaw , Gustavo Zamberlam , Marianne Villettaz Robichaud , Sophie Petropoulos , Julie Hussin , Juan Carlos Arango Sabogal , Julie Brind'Amour , Guillaume St-Jean , Pablo Valdes Donoso , Sarah Kimmins , Paul François , Anthony Estienne , Nicolas Gévry , Daniel J. Bernard , Cathy Vaillancourt , Jacquetta M Trasler , Hugh Clarke , Bernard Robaire , Guylain Boissonneault , Éric Asselin , Barbara F Hales , Makoto Nagano , Rima Slim , Rajesha Duggavathi , Carlos Reyes-Moreno , Roger I Cue , Roger I Cue , Marc-André Sirard , Robert Viger , François Richard , Pierre Leclerc , Jacques J. Tremblay , Édith Charbonneau , Vilceu Bordignon , Kessen Patten , Claude Robert , Yojiro Yamanaka , Daniel Cyr , Isabelle Plante , Géraldine Delbès , Debora Santschi , Elsa Vasseur , Elsa Vasseur , Guylaine Sauvé , Clémence Belleannée , Kevin Wade , Nicolas Pilon , Maritza Jaramillo Patino , Sylvie Breton , William Pastor , Abdoulaye Banire Diallo , Véronique Ouellet , Teruko Taketo-Hosotani , Aimee Ryan , Loydie Majewska , Cristian Marcel O'Flaherty , Laurence Charton , Philippe Constant , Cristiano Côrtes , Sylvain Riendeau
Funding sources: FRQNT/Fonds de recherche du Québec - Nature et technologies (FQRNT)
Grant programs: PVXXXXXX-(RS) Programme de regroupements stratégiques

Heterochromatin Protein 1 (HP1) in maternal infertility and embryonic development Projet de recherche au Canada / 2023 - 2030

Lead researcher : Julie Brind'Amour
Co-researchers : Greg Fitzharris
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Explore the relationship between the subcortical maternal complex (SCMC) and epigenetic remodeling during oogenesis and early embryogenesis Projet de recherche au Canada / 2023 - 2029

Lead researcher : Julie Brind'Amour
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVXXXXXX-(DGECR) Tremplin vers la découverte

Explore the relationship between the subcortical maternal complex (SCMC) and epigenetic remodeling during oogenesis and early embryogenesis Projet de recherche au Canada / 2023 - 2029

Lead researcher : Julie Brind'Amour
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)
Grant programs: PVX20965-(RGP) Programme de subvention à la découverte individuelle ou de groupe

Transcriptional Regulation of Human Trophoblast Development Projet de recherche au Canada / 2023 - 2026

Lead researcher : William Pastor
Co-researchers : Julie Brind'Amour
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Identification of early markers of epigenetic disorders in bovine production Projet de recherche au Canada / 2023 - 2026

Lead researcher : Julie Brind'Amour

Identification of early markers of developmental epigenetic anomalies in bovine production Projet de recherche au Canada / 2023 - 2026

Lead researcher : Julie Brind'Amour

Identification of early markers of epigenetic disorders in bovine production Projet de recherche au Canada / 2023 - 2026

Lead researcher : Julie Brind'Amour
Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG) , L'Alliance Boviteq inc. , MITACS Inc.
Grant programs: PVXXXXXX-Subventions Alliance - Mitacs Accélération , , PVXXXXXX-Stage Accélération Québec - MITACS

Identification of early markers of developmental epigenetic anomalies in bovine production Projet de recherche au Canada / 2022 - 2023

Lead researcher : Julie Brind'Amour
Funding sources: MITACS Inc.
Grant programs: PVXXXXXX-Stage Accélération Québec - MITACS

Publications Expand all Collapse all

Publications connexes:

*Bogutz AB, *Brind’Amour J, *Kobayashi H, Jensen KN, Nakabayashi K, Imai H, Lorincz MC#, and Lefebvre L#. Endogenous retroviruses direct the evolution of lineage-specific imprinting. Nature Commun. 2019. Dec 12;10(1):5674 *equal contribution

Brind’Amour J, Kobayashi H, Richard Albert J, Shirane K, Sakashita A, Kamio A, Bogutz A, Koike T, Karimi M.M, Lefebvre L.L, Kono T and Lorincz M.C. LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation. Nature Commun. 2018. Aug 20;9(1):3331

Brind'Amour J, Liu S, Hudson M, Chen C, Karimi MM, Lorincz MC. An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations. Nat Commun. 2015. Jan 21;6:6033.

*Liu S, *Brind'Amour J, Karimi MM, Shirane K, Bogutz A, Lefebvre L, Sasaki H, Shinkai Y, Lorincz MC. Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells. Genes Dev. 2014. Sep 15;28(18):2041-55. *equal contribution.

Commentaires:

Brind’Amour J and Lorincz MC. Setting the chromatin stage in oocytes. Nature Cell Biology. 2020. March 30. News and Views.

Brind'Amour J, Mager DL. Reality check for transposon enhancers. Elife. 2019. May 31. Highlight.

Contributions & collaborations:

Lismer A, Lafleur C, Siklenka K, Lambrot R, Brind’Amour J, Lorincz MC, Dumeaux V, Kimmins S. Paternal folate deficiency induces aberrant sperm histone H3 lysine 4 trimethylation which is transmitted to the embryo. Dev Cell. 2021 Mar 8;56(5):671-686.

Richard Albert J, Au Yeung WK, Toriyama K, Kobayashi H, Hirasawa R, Brind'Amour J, Bogutz AB, Sasaki H & Lorincz MC. Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo. Nature Commun. 2020. Oct 27; 11(5417)

Hu CK, *Wang W, *Brind’Amour J, Singh PP, Reeves GA, Lorincz MC, Sánchez Alvarado A, and Brunet A. Vertebrate diapause preserves organisms long-term via Polycomb complex members. Science. 2020. Feb 21;367(6480):870-874. *equal contribution

Qianhua Xu*, Yunlong Xiang*, Qiujun Wang*, Leyun Wang*, Julie Brind’Amour, Aaron Blair Bogutz, Yu Zhang, Bingjie Zhang, Guang Yu, Weikun Xia, Zhenhai Du, Chunyi Huang, Jing Ma, Hui Zheng, Yuanyuan Li, Chao Liu, Cheryl Lyn Walker, Eric Jonasch, Louis Lefebvre, Min Wu, Matthew Lorincz, Wei Li#, Li Li#, Wei Xie#. SETD2 regulates maternal epigenomic reprogramming and fertility. Nature Genetics. 2019. April 29. *equal contribution

Au Yeung WK, Brind’Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, and Sasaki H. Histone H3K9 methyltransferase G9a in oocyte is essential for preimplantation development but dispensable for CG demethylation protection. Cell Rep. 2019. Apr 2;27(1):282-293.e4

Communications Expand all Collapse all

Présentations invitées:

2021 Fragile Nucleosome Seminar Series. Online seminar (international audience).  “Maternally-inherited H3K27me3 inhibits enhancer commissioning and transcription in the early embryo.”

2019 CEEHRC/IHEC meeting (emergent researcher award). Banff, Canada. “Interplay between histone modifications and DNA methylation during oocyte development.”

2019 Alberta Children’s Hospital Research Institute. Calgary, Canada. “Interplay between transcription, histone modifications and DNA methylation during oogenesis and development.”

2019 Centre de Recherche en Reproduction et Fertilité (CRRF). Saint-Hyacinthe, Canada. “Impact of transcription on the establishment of the maternal epigenome.”

2019 Life Sciences Institute (LSI), University of British Columbia. Vancouver, Canada. “Interplay between histone modifications and DNA methylation during development.”

2018 Centre for Research in Reproduction and Development (CRRD), McGill University, Montreal, Canada. “Species-specific endogenous retroviruses drive widespread and heritable DNA methylation changes in oocytes.”

2016 39th Annual Meeting. Molecular Biology Society of Japan, Yokohama, Japan. “Impact of maternally inherited histone modifications on DNA methylation maintenance and enhancer activation in the early embryo.”

2016 Canadian Fertility and Andrology Society (CFAS) Workshop, Vancouver, Canada. “Maternal epigenetic contribution to the early embryo.”

2015 Stem Cell Network (SCN) OMICS Workshop, Toronto, Canada. “Ultra-low-input ChIP-seq for rare cell populations: expectations and realities.”

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